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TargetHistone deacetylase (HDAC1 and HDAC2)
LigandBDBM50220793
Substrate/Competitorn/a
Meas. Tech.ChEMBL_87404 (CHEMBL693168)
IC50 12±n/a nM
Citation Dai, YGuo, YGuo, JPease, LJLi, JMarcotte, PAGlaser, KBTapang, PAlbert, DHRichardson, PLDavidsen, SKMichaelides, MR Indole amide hydroxamic acids as potent inhibitors of histone deacetylases. Bioorg Med Chem Lett13:1897-901 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase (HDAC1 and HDAC2)
Name:Histone deacetylase (HDAC1 and HDAC2)
Synonyms:HDACs | Histone deacetylase 1/2
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 2197604
Components:This complex has 2 components.
Component 1
Name:Histone deacetylase 1
Synonyms:Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:Enzyme
Mol. Mass.:55090.27
Organism:Homo sapiens (Human)
Description:Q13547
Residue:482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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Component 2
Name:Histone deacetylase 2
Synonyms:Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:Chromatin regulator; hydrolase; repressor
Mol. Mass.:55356.54
Organism:Homo sapiens (Human)
Description:Q92769
Residue:488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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BDBM50220793
n/a
NameBDBM50220793
Synonyms:CHEMBL54408
TypeSmall organic molecule
Emp. Form.C22H24FN3O3
Mol. Mass.397.4427
SMILESONC(=O)CCCCCCNC(=O)c1cn(-c2ccc(F)cc2)c2ccccc12
Structure
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