| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Ligand | BDBM50221018 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_212282 (CHEMBL819149) |
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| IC50 | 47400±n/a nM |
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| Citation |  Li, Z; Francisco, GD; Hu, W; Labthavikul, P; Petersen, PJ; Severin, A; Singh, G; Yang, Y; Rasmussen, BA; Lin, YI; Skotnicki, JS; Mansour, TS 2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett13:2591-4 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Name: | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Synonyms: | MURD_STAAU | MurD (S. aureus) | murD |
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| Type: | Protein |
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| Mol. Mass.: | 49837.61 |
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| Organism: | Staphylococcus aureus (Firmicutes) |
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| Description: | S. aureus MurD |
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| Residue: | 449 |
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| Sequence: | MLNYTGLENKNVLVVGLAKSGYEAAKLLSKLGANVTVNDGKDLSQDAHAKDLESMGISVV
SGSHPLTLLDNNPIIVKNPGIPYTVSIIDEAVKRGLKILTEVELSYLISEAPIIAVTGTN
GKTTVTSLIGDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDYLVTELSSFQLLGIEKYKP
HIAIITNIYSAHLDYHENLENYQNAKKQIYKNQTEEDYLICNYHQRQVIESEELKAKTLY
FSTQQEVDGIYIKDGFIVYKGVRIINTEDLVLPGEHNLENILAAVLACILAGVPIKAIID
SLTTFSGIEHRLQYVGTNRTNKYYNDSKATNTLATQFALNSFNQPIIWLCGGLDRGNEFD
ELIPYMENVRAMVVFGQTKAKFAKLGNSQGKSVIEANNVEDAVDKVQDIIEPNDVVLLSP
ACASWDQYSTFEERGEKFIERFRAHLPSY
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| BDBM50221018 |
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| n/a |
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| Name | BDBM50221018 |
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| Synonyms: | CHEMBL85772 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H9ClN2OS |
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| Mol. Mass. | 252.72 |
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| SMILES | Oc1c2SCCc2nn1-c1ccc(Cl)cc1 |
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| Structure | 
|
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