| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramate--L-alanine ligase |
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| Ligand | BDBM50221019 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_212278 (CHEMBL816141) |
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| IC50 | >93700±n/a nM |
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| Citation |  Li, Z; Francisco, GD; Hu, W; Labthavikul, P; Petersen, PJ; Severin, A; Singh, G; Yang, Y; Rasmussen, BA; Lin, YI; Skotnicki, JS; Mansour, TS 2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett13:2591-4 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-N-acetylmuramate--L-alanine ligase |
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| Name: | UDP-N-acetylmuramate--L-alanine ligase |
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| Synonyms: | MURC_STAAU | MurC (S. aureus) | UDP-N-acetylmuramoyl-L-alanine synthetase | murC |
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| Type: | Protein |
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| Mol. Mass.: | 49159.53 |
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| Organism: | Staphylococcus aureus (Firmicutes) |
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| Description: | S. aureus MurC |
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| Residue: | 437 |
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| Sequence: | MTHYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKE
DMVVIQGNAFASSHEEKARAHQMKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLS
HVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLSYKPDYAIMTNIDFDHPDYFK
DINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKG
TAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFN
ETTIANQVIVDDYAHHPREISATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLS
KADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDSINVLEQFDNAVVLFKGAGDI
QKLQNAYLDKLGMKNAF
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| BDBM50221019 |
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| n/a |
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| Name | BDBM50221019 |
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| Synonyms: | CHEMBL87584 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H11ClN2OS |
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| Mol. Mass. | 266.747 |
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| SMILES | CC1Cc2nn(c(O)c2S1)-c1ccc(Cl)cc1 |
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| Structure | 
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