| Reaction Details |
|---|
 | Report a problem with these data |
| Target | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
|---|
| Ligand | BDBM50221031 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_212282 (CHEMBL819149) |
|---|
| IC50 | >96000±n/a nM |
|---|
| Citation |  Li, Z; Francisco, GD; Hu, W; Labthavikul, P; Petersen, PJ; Severin, A; Singh, G; Yang, Y; Rasmussen, BA; Lin, YI; Skotnicki, JS; Mansour, TS 2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett13:2591-4 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| UDP-N-acetylmuramoylalanine--D-glutamate ligase |
|---|
| Name: | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
|---|
| Synonyms: | MURD_STAAU | MurD (S. aureus) | murD |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 49837.61 |
|---|
| Organism: | Staphylococcus aureus (Firmicutes) |
|---|
| Description: | S. aureus MurD |
|---|
| Residue: | 449 |
|---|
| Sequence: | MLNYTGLENKNVLVVGLAKSGYEAAKLLSKLGANVTVNDGKDLSQDAHAKDLESMGISVV
SGSHPLTLLDNNPIIVKNPGIPYTVSIIDEAVKRGLKILTEVELSYLISEAPIIAVTGTN
GKTTVTSLIGDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDYLVTELSSFQLLGIEKYKP
HIAIITNIYSAHLDYHENLENYQNAKKQIYKNQTEEDYLICNYHQRQVIESEELKAKTLY
FSTQQEVDGIYIKDGFIVYKGVRIINTEDLVLPGEHNLENILAAVLACILAGVPIKAIID
SLTTFSGIEHRLQYVGTNRTNKYYNDSKATNTLATQFALNSFNQPIIWLCGGLDRGNEFD
ELIPYMENVRAMVVFGQTKAKFAKLGNSQGKSVIEANNVEDAVDKVQDIIEPNDVVLLSP
ACASWDQYSTFEERGEKFIERFRAHLPSY
|
|
|
|---|
| BDBM50221031 |
|---|
| n/a |
|---|
| Name | BDBM50221031 |
|---|
| Synonyms: | CHEMBL315456 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H16N2OS |
|---|
| Mol. Mass. | 260.355 |
|---|
| SMILES | CC(C)c1ccc(cc1)-n1nc2CCSc2c1O |
|---|
| Structure | 
|
|---|
Search and Browse
