| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase (HDAC1 and HDAC2) |
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| Ligand | BDBM50221810 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_87403 (CHEMBL693167) |
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| IC50 | 9.5±n/a nM |
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| Citation |  Wada, CK; Frey, RR; Ji, Z; Curtin, ML; Garland, RB; Holms, JH; Li, J; Pease, LJ; Guo, J; Glaser, KB; Marcotte, PA; Richardson, PL; Murphy, SS; Bouska, JJ; Tapang, P; Magoc, TJ; Albert, DH; Davidsen, SK; Michaelides, MR Alpha-keto amides as inhibitors of histone deacetylase. Bioorg Med Chem Lett13:3331-5 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Histone deacetylase (HDAC1 and HDAC2) |
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| Name: | Histone deacetylase (HDAC1 and HDAC2) |
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| Synonyms: | HDACs | Histone deacetylase 1/2 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 2197604 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| Component 2 |
| Name: | Histone deacetylase 2 |
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| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 55356.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92769 |
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| Residue: | 488 |
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| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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| BDBM50221810 |
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| n/a |
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| Name | BDBM50221810 |
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| Synonyms: | CHEMBL111898 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N3O3 |
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| Mol. Mass. | 341.4042 |
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| SMILES | CNC(=O)C(=O)CCCCCCC(=O)Nc1cnc2ccccc2c1 |
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| Structure | 
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