| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 1/2 |
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| Ligand | BDBM50222124 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_50962 (CHEMBL666044) |
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| Ki | 0.500000±n/a nM |
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| Citation |  Arvanitis, AG; Arnold, CR; Fitzgerald, LW; Frietze, WE; Olson, RE; Gilligan, PJ; Robertson, DW CRF ligands via Suzuki and Negishi couplings of 3-pyridyl boronic acids or halides with 2-benzyloxy-4-chloro-3-nitropyridine. Bioorg Med Chem Lett13:289-91 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin-releasing factor receptor 1/2 |
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| Name: | Corticotropin-releasing factor receptor 1/2 |
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| Synonyms: | Corticotropin releasing factor receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 217368 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Corticotropin-releasing factor receptor 1 |
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| Synonyms: | CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 47870.75 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Receptor binding assays were performed using rat cortex homogenate. |
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| Residue: | 415 |
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| Sequence: | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
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| Component 2 |
| Name: | Corticotropin-releasing factor receptor 2 |
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| Synonyms: | CRF-R-2 | CRF-R2 | CRF2 Beta | CRFR-2 | CRFR2_RAT | CRH-R-2 | CRH-R2 | Corticotropin releasing factor receptor | Corticotropin-releasing factor receptor 2 | Corticotropin-releasing hormone receptor 2 | Crf2r | Crhr2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47697.09 |
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| Organism: | RAT |
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| Description: | CRF2 Beta 0 RAT::P47866 |
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| Residue: | 411 |
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| Sequence: | MDAALLLSLLEANCSLALAEELLLDGWGEPPDPEGPYSYCNTTLDQIGTCWPQSAPGALV
ERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIIN
YLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNITWFLLQLIDHEVHEGN
EVWCRCVTTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIV
AWAVGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYC
FFNGEVRSALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
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| BDBM50222124 |
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| n/a |
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| Name | BDBM50222124 |
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| Synonyms: | CHEMBL97340 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N3O |
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| Mol. Mass. | 349.4693 |
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| SMILES | CCC(C1CC1)n1c(CC)nc2c(ccnc12)-c1ccc(OC)cc1C |
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| Structure | 
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