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Reaction Details
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TargetDihydrofolate reductase
LigandBDBM50405069
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54925 (CHEMBL857514)
Ki 4.6±n/a nM
Citation Coats, EAGenther, CSDietrich, SWGuo, ZRHansch, C Comparison of the inhibition of methotrexate-sensitive and -resistant Lactobacillus casei cell cultures with purified Lactobacillus casei dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-substituted-phenyl)-s-triazines. Use of quantitative structure-activity relationships in maki J Med Chem24:1422-9 (1981) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_LACCA | dhfR | folA
Type:PROTEIN
Mol. Mass.:18437.08
Organism:Lactobacillus casei
Description:ChEMBL_1357878
Residue:163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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BDBM50405069
n/a
NameBDBM50405069
Synonyms:CHEMBL287235
TypeSmall organic molecule
Emp. Form.C23H39N5O
Mol. Mass.401.5887
SMILESCCCCCCCCCCCCOc1cccc(c1)N1C(N)=NC(N)=NC1(C)C |c:22,25|
Structure
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