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TargetDihydrofolate reductase
LigandBDBM50029760
Substrate/Competitorn/a
Meas. Tech.ChEMBL_53943 (CHEMBL668662)
Ki 13183±n/a nM
Citation Li, RLDietrich, SWHansch, C Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines. J Med Chem24:538-44 (1981) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR)
Type:Enzyme
Mol. Mass.:21603.71
Organism:Bos taurus (Cattle)
Description:P00376
Residue:187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
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BDBM50029760
n/a
NameBDBM50029760
Synonyms:5-[3,5-Dimethoxy-4-(2-methoxy-ethoxy)-benzyl]-pyrimidine-2,4-diamine | 5-[3,5-Dimethoxy-4-(2-methoxy-ethoxy)-benzyl]-pyrimidine-2,4-diamine(Tetroxoprim ) | CHEMBL32039 | Tetroxoprim
TypeSmall organic molecule
Emp. Form.C16H22N4O4
Mol. Mass.334.3703
SMILESCOCCOc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC
Structure
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