| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D(1A)/D(2) dopamine receptor |
|---|
| Ligand | BDBM50224035 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_59595 (CHEMBL672152) |
|---|
| IC50 | 4500±n/a nM |
|---|
| Citation |  Cannon, JG; Perez, JA; Bhatnagar, RK; Long, JP; Sharabi, FM Conformationally restricted congeners of dopamine derived from 2-aminoindan. J Med Chem25:1442-6 (1982) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D(1A)/D(2) dopamine receptor |
|---|
| Name: | D(1A)/D(2) dopamine receptor |
|---|
| Synonyms: | Dopamine receptor |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 59578 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | D(2) dopamine receptor |
|---|
| Synonyms: | DOPAMINE D2 | DRD2 | DRD2_BOVIN | Dopamine D2 receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 50698.79 |
|---|
| Organism: | BOVINE |
|---|
| Description: | P20288 |
|---|
| Residue: | 444 |
|---|
| Sequence: | MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFLKILHC
|
|
|
|---|
| Component 2 |
| Name: | D(1A) dopamine receptor |
|---|
| Synonyms: | D(1A) dopamine receptor | D1AR | DOPAMINE D1 | DRD1 | DRD1_BOVIN | Dopamine receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 49330.65 |
|---|
| Organism: | BOVINE |
|---|
| Description: | DOPAMINE D1 DRD1 BOVINE::Q95136 |
|---|
| Residue: | 446 |
|---|
| Sequence: | MRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLG
KTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKN
CQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGS
GETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIET
VSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
|
|
|
|---|
| BDBM50224035 |
|---|
| n/a |
|---|
| Name | BDBM50224035 |
|---|
| Synonyms: | 79907 | Lergotrile |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H18ClN3 |
|---|
| Mol. Mass. | 299.798 |
|---|
| SMILES | [H][C@@]12Cc3c(Cl)[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CC#N)CN2C |
|---|
| Structure | 
|
|---|
Search and Browse
