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TargetDihydrofolate reductase
LigandBDBM50405072
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54084 (CHEMBL669981)
Ki 76±n/a nM
Citation Hathaway, BAGuo, ZRHansch, CDelcamp, TJSusten, SSFreisheim, JH Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis. J Med Chem27:144-9 (1984) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50405072
n/a
NameBDBM50405072
Synonyms:CHEMBL33010
TypeSmall organic molecule
Emp. Form.C19H23N5O2
Mol. Mass.353.4182
SMILESCC1(C)N=C(N)N=C(N)N1c1ccc(OCc2ccc(CO)cc2)cc1 |t:3,6|
Structure
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