| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrofolate reductase |
|---|
| Ligand | BDBM50090075 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_54084 (CHEMBL669981) |
|---|
| Ki | 1738±n/a nM |
|---|
| Citation |  Hathaway, BA; Guo, ZR; Hansch, C; Delcamp, TJ; Susten, SS; Freisheim, JH Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis. J Med Chem27:144-9 (1984) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrofolate reductase |
|---|
| Name: | Dihydrofolate reductase |
|---|
| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 21453.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human DHFR. |
|---|
| Residue: | 187 |
|---|
| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
|---|
| BDBM50090075 |
|---|
| n/a |
|---|
| Name | BDBM50090075 |
|---|
| Synonyms: | 1-(4-Bromo-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diamine | CHEMBL6741 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H14BrN5 |
|---|
| Mol. Mass. | 296.166 |
|---|
| SMILES | CC1(C)N=C(N)N=C(N)N1c1ccc(Br)cc1 |t:3,6| |
|---|
| Structure | 
|
|---|
Search and Browse
