| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase type 1 |
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| Ligand | BDBM50291785 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54572 (CHEMBL664886) |
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| Ki | 537±n/a nM |
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| Citation |  Coats, EA; Genther, CS; Selassie, CD; Strong, CD; Hansch, C Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate. J Med Chem28:1910-6 (1985) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase type 1 |
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| Name: | Dihydrofolate reductase type 1 |
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| Synonyms: | DYR1_ECOLX | dhfrI |
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| Type: | PROTEIN |
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| Mol. Mass.: | 17574.87 |
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| Organism: | Escherichia coli |
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| Description: | ChEMBL_54248 |
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| Residue: | 157 |
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| Sequence: | MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI
EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG
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| BDBM50291785 |
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| n/a |
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| Name | BDBM50291785 |
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| Synonyms: | 6,6-Dimethyl-1-(3-m-tolyloxymethyl-phenyl)-1,6-dihydro-[1,3,5]triazine-2,4-diamine | CHEMBL20480 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N5O |
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| Mol. Mass. | 337.4188 |
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| SMILES | Cc1cccc(OCc2cccc(c2)N2C(N)=NC(N)=NC2(C)C)c1 |c:17,20| |
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| Structure | 
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