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TargetDihydrofolate reductase type 1
LigandBDBM50405076
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54572 (CHEMBL664886)
Ki 708±n/a nM
Citation Coats, EAGenther, CSSelassie, CDStrong, CDHansch, C Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate. J Med Chem28:1910-6 (1985) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase type 1
Name:Dihydrofolate reductase type 1
Synonyms:DYR1_ECOLX | dhfrI
Type:PROTEIN
Mol. Mass.:17574.87
Organism:Escherichia coli
Description:ChEMBL_54248
Residue:157
Sequence:
MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI
EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG
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BDBM50405076
n/a
NameBDBM50405076
Synonyms:CHEMBL269704
TypeSmall organic molecule
Emp. Form.C18H19Cl2N5O
Mol. Mass.392.282
SMILESCC1(C)N=C(N)N=C(N)N1c1cccc(OCc2ccc(Cl)c(Cl)c2)c1 |t:3,6|
Structure
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