Reaction Details |
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Target | Dihydrofolate reductase type 1 |
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Ligand | BDBM50291789 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54572 (CHEMBL664886) |
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Ki | 977±n/a nM |
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Citation | Coats, EA; Genther, CS; Selassie, CD; Strong, CD; Hansch, C Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate. J Med Chem28:1910-6 (1985) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase type 1 |
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Name: | Dihydrofolate reductase type 1 |
Synonyms: | DYR1_ECOLX | dhfrI |
Type: | PROTEIN |
Mol. Mass.: | 17574.87 |
Organism: | Escherichia coli |
Description: | ChEMBL_54248 |
Residue: | 157 |
Sequence: | MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI
EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG
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BDBM50291789 |
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n/a |
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Name | BDBM50291789 |
Synonyms: | 1-[3-(3-Chloro-phenoxymethyl)-phenyl]-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diamine | CHEMBL417461 | xv1-[3-(3-Chloro-phenoxymethyl)-phenyl]-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diamine |
Type | Small organic molecule |
Emp. Form. | C18H20ClN5O |
Mol. Mass. | 357.837 |
SMILES | CC1(C)N=C(N)N=C(N)N1c1cccc(COc2cccc(Cl)c2)c1 |t:3,6| |
Structure |
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