| Reaction Details |
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 | Report a problem with these data |
| Target | Chymotrypsin-like elastase family member 1/2A |
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| Ligand | BDBM50226397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_158072 (CHEMBL764901) |
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| Ki | 42500±n/a nM |
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| Citation |  Digenis, GA; Agha, BJ; Tsuji, K; Kato, M; Shinogi, M Peptidyl carbamates incorporating amino acid isosteres as novel elastase inhibitors. J Med Chem29:1468-76 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Chymotrypsin-like elastase family member 1/2A |
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| Name: | Chymotrypsin-like elastase family member 1/2A |
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| Synonyms: | Pancreatic elastase |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 152345 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Chymotrypsin-like elastase family member 1 |
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| Synonyms: | CELA1 | CELA1_PIG | ELA1 | Elastase | Elastase 1 | Elastase-1 | Pancreatic elastase |
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| Type: | Enzyme |
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| Mol. Mass.: | 28827.71 |
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| Organism: | Sus scrofa (Pig) |
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| Description: | P00772 |
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| Residue: | 266 |
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| Sequence: | MLRLLVVASLVLYGHSTQDFPETNARVVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTL
IRQNWVMTAAHCVDRELTFRVVVGEHNLNQNDGTEQYVGVQKIVVHPYWNTDDVAAGYDI
ALLRLAQSVTLNSYVQLGVLPRAGTILANNSPCYITGWGLTRTNGQLAQTLQQAYLPTVD
YAICSSSSYWGSTVKNSMVCAGGDGVRSGCQGDSGGPLHCLVNGQYAVHGVTSFVSRLGC
NVTRKPTVFTRVSAYISWINNVIASN
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| Component 2 |
| Name: | Chymotrypsin-like elastase family member 2A |
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| Synonyms: | CEL2A_PIG | CELA2A | ELA2 | ELA2A | Elastase 2A | Elastase-2 | Elastase-2A | Pancreatic elastase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28705.23 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_156951 |
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| Residue: | 269 |
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| Sequence: | MIRALLLSTLVAGALSCGLPANLPQLPRVVGGEDARPNSWPWQVSLQYDSSGQWRHTCGG
TLVDQSWVLTAAHCISSSRTYRVVLGRHSLSTNEPGSLAVKVSKLVVHQDWNSNQLSNGN
DIALLKLASPVSLTDKIQLGCLPAAGTILPNNYVCYVTGWGRLQTNGASPDILQQGQLLV
VDYATCSKPGWWGSTVKTNMICAGGDGIISSCNGDSGGPLNCQGANGQWQVHGIVSFGSS
LGCNYYHKPSVFTRVSNYIDWINSVIANN
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| BDBM50226397 |
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| n/a |
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| Name | BDBM50226397 |
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| Synonyms: | CHEMBL3143925 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H37N5O10 |
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| Mol. Mass. | 591.6102 |
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| SMILES | COC(=O)CCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)CN(C(C)C)C(=O)Oc1ccc(cc1)[N+]([O-])=O |r| |
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| Structure | 
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