| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrofolate reductase |
|---|
| Ligand | BDBM50027975 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_54735 (CHEMBL667186) |
|---|
| Ki | 0.040±n/a nM |
|---|
| Citation |  Doweyko, AM The hypothetical active site lattice. An approach to modelling active sites from data on inhibitor molecules. J Med Chem31:1396-406 (1988) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrofolate reductase |
|---|
| Name: | Dihydrofolate reductase |
|---|
| Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 17532.46 |
|---|
| Organism: | Escherichia coli |
|---|
| Description: | n/a |
|---|
| Residue: | 157 |
|---|
| Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
|
|
|
|---|
| BDBM50027975 |
|---|
| n/a |
|---|
| Name | BDBM50027975 |
|---|
| Synonyms: | 5-[2-Bromo-5-(2,4-diamino-pyrimidin-5-ylmethyl)-3-methoxy-phenoxy]-pentanoic acid | CHEMBL31924 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H21BrN4O4 |
|---|
| Mol. Mass. | 425.277 |
|---|
| SMILES | COc1cc(Cc2cnc(N)nc2N)cc(OCCCCC(O)=O)c1Br |
|---|
| Structure | 
|
|---|
Search and Browse
