| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50391257 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54735 (CHEMBL667186) |
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| Ki | 0.490±n/a nM |
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| Citation |  Doweyko, AM The hypothetical active site lattice. An approach to modelling active sites from data on inhibitor molecules. J Med Chem31:1396-406 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
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| Type: | n/a |
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| Mol. Mass.: | 17532.46 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 157 |
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| Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
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| BDBM50391257 |
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| n/a |
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| Name | BDBM50391257 |
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| Synonyms: | CHEMBL30938 | Ro-17-3279 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25N5O2 |
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| Mol. Mass. | 355.4341 |
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| SMILES | COc1cc(OC)cc(c1)N1C2CCC1CC(C2)c1cnc(N)nc1N |TLB:18:16:10:12.13| |
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| Structure | 
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