| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-1/Beta-2/Beta-3 adrenergic receptor |
|---|
| Ligand | BDBM50227818 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_38884 (CHEMBL652715) |
|---|
| Ki | 12000±n/a nM |
|---|
| Citation |  Wu, ES; Cole, TE; Davidson, TA; Dailey, MA; Doring, KG; Fedorchuk, M; Loch, JT; Thomas, TL; Blosser, JC; Borrelli, AR Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties. J Med Chem32:183-92 (1989) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-1/Beta-2/Beta-3 adrenergic receptor |
|---|
| Name: | Beta-1/Beta-2/Beta-3 adrenergic receptor |
|---|
| Synonyms: | Adrenergic receptor beta |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 1340543 |
|---|
| Components: | This complex has 3 components. |
|---|
| Component 1 |
| Name: | Beta-1 adrenergic receptor |
|---|
| Synonyms: | ADRB1R, B1AR | ADRB1_RAT | Adrb1 | Adrb1r | Adrenergic receptor beta | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 | adrenergic Beta1,2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 50486.84 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P18090 |
|---|
| Residue: | 466 |
|---|
| Sequence: | MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAG
MGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRP
SRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSA
FNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDD
DDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
|
|
|
|---|
| Component 2 |
| Name: | Beta-2 adrenergic receptor |
|---|
| Synonyms: | ADRB2_RAT | Adrb2 | Adrb2r | Adrenergic receptor beta |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 46896.26 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_38603 |
|---|
| Residue: | 418 |
|---|
| Sequence: | MEPHGNDSDFLLAPNGSRAPGHDITQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHKQ
AIDCYAKETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRF
HAQNLSQVEQDGRSGHGLRSSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRA
NLIPKEVYILLNWLGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSSKTYGNGYSSNSNG
RTDYTGEQSAYQLGQEKENELLCEEAPGMEGFVNCQGTVPSLSIDSQGRNCNTNDSPL
|
|
|
|---|
| Component 3 |
| Name: | Beta-3 adrenergic receptor |
|---|
| Synonyms: | ADRB3_RAT | Adrb3 | Adrb3r | Adrenergic receptor beta | Beta-3 adrenergic receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 43161.83 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1509452 |
|---|
| Residue: | 400 |
|---|
| Sequence: | MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIA
RTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTA
SIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGAD
AEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELG
RFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSL
CWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSY
GGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT
|
|
|
|---|
| BDBM50227818 |
|---|
| n/a |
|---|
| Name | BDBM50227818 |
|---|
| Synonyms: | CHEMBL56023 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H23NO4 |
|---|
| Mol. Mass. | 353.4116 |
|---|
| SMILES | CC(C)NCC(O)COc1ccc2c(c1)oc(cc2=O)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
