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TargetProstaglandin G/H synthase 1/2
LigandBDBM50174201
Substrate/Competitorn/a
Meas. Tech.ChEMBL_157972 (CHEMBL858257)
IC50 1000000000±n/a nM
Citation Moser, PSallmann, AWiesenberg, I Synthesis and quantitative structure-activity relationships of diclofenac analogues. J Med Chem33:2358-68 (1990) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin G/H synthase 1/2
Name:Prostaglandin G/H synthase 1/2
Synonyms:Cyclooxygenase
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 1570295
Components:This complex has 2 components.
Component 1
Name:Prostaglandin G/H synthase 2
Synonyms:COX2 | Cyclooxygenase | Cyclooxygenase-2 | PGH synthase 2 | PGH2_BOVIN | PGHS-2 | PHS II | PTGS2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Type:PROTEIN
Mol. Mass.:69173.20
Organism:Bos taurus
Description:ChEMBL_157990
Residue:604
Sequence:
MLARALLLCAAVALSGAANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNKISFLRNMIMRYVLTSRSHLIESPPTYNVHY
SYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGRKELPDSKEVVKKVLLRRKFIPDPQGT
NLMFAFFAQHFTHQFFKTDFERGPAFTKGKNHGVDLSHIYGESLERQHKLRLFKDGKMKY
QMINGEMYPPTVKDTQVEMIYPPHVPEHLKFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIAAEFNTLYHWHPLLPDVFQIDGQEYNYQQFIYNNSVLLEHGLTQFVESFTRQRAGRV
AGGRNLPVAVEKVSKASIDQSREMKYQSFNEYRKRFLVKPYESFEELTGEKEMAAELEAL
YGDIDAMEFYPALLVEKPRPDAIFGETMVEAGAPFSLKGLMGNPICSPEYWKPSTFGGEV
GFKIINTASIQSLICSNVKGCPFTSFSVQDTHLTKTVTINASSSHSGLDDINPTVLLKER
STEL
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Component 2
Name:Prostaglandin G/H synthase 1
Synonyms:COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | PGH1_BOVIN | PTGS1
Type:PROTEIN
Mol. Mass.:68814.10
Organism:Bos taurus
Description:ChEMBL_547440
Residue:600
Sequence:
MSRQGISLRFPLLLLLLSPSPVLPADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCT
RTGYYGPNCTIPEIWTWLRTTLRPSPSFVHFLLTHGRWLWDFVNATFIRDKLMRLVLTVR
SNLIPSPPTYNVAHDYISWESFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRR
FLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLER
QYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMV
YATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLK
FDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVE
ALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRELRLQPFNEYRKRFGMKPYTSFQE
LTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPIC
SPEYWKASTFGGDVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPHREDRPGVERPPTEL
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BDBM50174201
n/a
NameBDBM50174201
Synonyms:ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-dichloro-phenylamino)-phenyl]-acetate | US11173137, Compound Diclofenac | VOLTAREN | VOLTAREN-XR | diclofenac sodium | sodium 2-(2-(2,6-dichlorophenylamino)phenyl)acetate
TypeSmall organic molecule
Emp. Form.C14H10Cl2NO2
Mol. Mass.295.141
SMILES[O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Structure
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