| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
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| Ligand | BDBM50229878 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_155690 (CHEMBL766267) |
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| IC50 | 70000±n/a nM |
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| Citation |  Bonnet, PA; Michel, A; Laurent, F; Sablayrolles, C; Rechencq, E; Mani, JC; Boucard, M; Chapat, JP Synthesis and antibronchospastic activity of 8-alkoxy- and 8-(alkylamino)imidazo[1,2-a]pyrazines. J Med Chem35:3353-8 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
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| Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
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| Synonyms: | 63 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Cam-PDE 1B | PDE1B | PDE1B1 | PDE1B_BOVIN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60991.90 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_104913 |
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| Residue: | 534 |
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| Sequence: | MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLE
YTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQTRAKGPSEEKPKF
RSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNVDLWCFDVFSLNRAADDHALRT
IVFELLTRHNLISRFKIPTVFLMTFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRT
GMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFR
MMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKSMKTALQQLERIDKSKAL
SLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQI
GFIDFIVEPTFSVLTDVAEKSVQPTGDDDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFR
STWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPASPAEDEHNQNGNLD
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| BDBM50229878 |
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| n/a |
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| Name | BDBM50229878 |
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| Synonyms: | CHEMBL112904 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H6BrN5 |
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| Mol. Mass. | 252.071 |
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| SMILES | CNc1nc(Br)cn2cc(nc12)C#N |
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| Structure | 
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