Ki Summary

Reaction Details

Report a problem with these data

Target

Lutropin-choriogonadotropic hormone receptor

Ligand

BDBM50230125

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_100017 (CHEMBL709254)

2.6±n/a nM

Citation

Haviy, F; Fitzpatrick, TD; Nichols, CJ; Swenson, RE; Bush, EN; Diaz, G; Nguyen, A; Nellans, HN; Hoffman, DJ; Ghanbari, H Stabilization of the N-terminal residues of luteinizing hormone-releasing hormone agonists and the effect on pharmacokinetics. J Med Chem35:3890-4 (1992) [PubMed]

More Info.:

Get all data from this article, Assay Method

Lutropin-choriogonadotropic hormone receptor

Name:

Lutropin-choriogonadotropic hormone receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

78049.26

Organism:

Rattus norvegicus

Description:

ChEMBL_97289

Residue:

700

Sequence:

MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSL
TYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEP
GAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNES
VTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQA
LPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSI
FENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDI
MGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIA
SVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQ
KLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNV
VAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKV
PLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEF
SAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH

BDBM50230125

n/a

Name

BDBM50230125

Synonyms:

CHEMBL274682

Type

Small organic molecule

Emp. Form.

C59H86N16O12

Mol. Mass.

1211.4141

SMILES

CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(C)C(C)=O |wU:39.49,57.71,31.36,23.28,wD:51.55,12.20,5.4,71.82,(26.08,-5.67,;26.47,-7.16,;27.96,-7.58,;29.03,-8.67,;30.53,-8.31,;28.61,-10.15,;29.55,-11.37,;28.68,-12.66,;27.21,-12.23,;27.15,-10.69,;25.87,-9.83,;25.98,-8.29,;24.49,-10.5,;24.38,-12.03,;25.66,-12.91,;25.54,-14.44,;26.82,-15.3,;26.7,-16.84,;28,-17.7,;25.33,-17.51,;23.21,-9.63,;21.83,-10.31,;21.71,-11.85,;20.55,-9.43,;20.65,-7.9,;22.04,-7.23,;23.31,-8.09,;22.15,-5.7,;19.16,-10.12,;17.88,-9.26,;17.99,-7.71,;16.49,-9.94,;16.39,-11.47,;17.14,-12.8,;18.67,-12.82,;16.37,-14.14,;15.21,-9.06,;13.84,-9.73,;13.72,-11.28,;12.56,-8.88,;12.66,-7.34,;14.05,-6.67,;15.33,-7.53,;16.71,-6.86,;16.81,-5.32,;18.21,-4.64,;15.54,-4.44,;14.16,-5.13,;11.17,-9.55,;9.89,-8.69,;9.99,-7.15,;8.5,-9.36,;8.39,-10.9,;9.68,-11.77,;7.23,-8.5,;5.83,-9.18,;5.72,-10.71,;4.56,-8.31,;4.67,-6.78,;6.06,-6.11,;7.59,-5.88,;7.85,-4.37,;6.5,-3.64,;6.14,-2.14,;4.65,-1.72,;3.54,-2.79,;3.91,-4.28,;5.39,-4.71,;3.18,-8.98,;1.89,-8.12,;2,-6.58,;.52,-8.8,;.4,-10.34,;1.68,-11.2,;1.73,-12.74,;3.21,-13.17,;4.07,-11.89,;3.12,-10.66,;-.77,-7.94,;-2.15,-8.61,;-2.27,-10.15,;-3.32,-7.82,;-4.43,-8.62,;-4.55,-10.15,;-5.52,-7.54,;-7,-7.95,;-5.13,-6.07,)|

Structure