Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50230678

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_48424 (CHEMBL660352)

1.4±n/a nM

Citation

Higginbottom, M; Kneen, C; Ratcliffe, GS Rationally designed"dipeptoid" analogues of CCK. A Free-Wilson/Fujita-Ban analysis of some alpha-methyltryptophan derivatives as CCK-B antagonists. J Med Chem35:1572-7 (1992) [PubMed]

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49196.59

Organism:

MOUSE

Description:

Cholecystokinin A CCKBR MOUSE::P56481

Residue:

453

Sequence:

MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGL
ISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCY
VQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANT
WRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPR
ARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50230678

n/a

Name

BDBM50230678

Synonyms:

CHEMBL287735

Type

Small organic molecule

Emp. Form.

C35H42N4O6

Mol. Mass.

614.7312

SMILES

C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1 |wU:1.1,30.35,wD:1.0,TLB:18:19:16.17.22:23,15:16:23:19.25.20,THB:18:17:23:19.25.20,20:19:16:21.22.23,20:21:16:19.18.25,(10.04,-3.61,;10.44,-2.12,;11.77,-2.89,;11.76,-4.44,;10.49,-5.31,;10.97,-6.79,;12.51,-6.79,;13.53,-7.95,;15.04,-7.63,;15.52,-6.17,;14.49,-5.02,;12.99,-5.35,;8.93,-1.81,;7.92,-2.97,;8.4,-4.44,;6.4,-2.68,;5.38,-3.84,;3.89,-3.61,;2.73,-4.41,;3.13,-5.83,;2.32,-7.36,;3.64,-6.59,;3.22,-5.06,;5.15,-6.76,;5.78,-5.3,;4.53,-5.98,;11.45,-.96,;10.97,.5,;12.96,-1.26,;13.99,-.11,;15.5,-.4,;16,-1.87,;17.52,-2.19,;18.01,-3.64,;18.52,-1.03,;20.03,-1.33,;21.06,-.17,;22.57,-.46,;20.57,1.31,;16.53,.74,;16.02,2.21,;17.04,3.36,;18.55,3.05,;19.06,1.6,;18.04,.44,)|

Structure