Reaction Details |
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Target | Receptor-interacting serine/threonine-protein kinase 1 |
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Ligand | BDBM50229242 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1644186 |
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EC50 | 490±n/a nM |
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Citation | Ren, Y; Su, Y; Sun, L; He, S; Meng, L; Liao, D; Liu, X; Ma, Y; Liu, C; Li, S; Ruan, H; Lei, X; Wang, X; Zhang, Z Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome. J Med Chem60:972-986 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Receptor-interacting serine/threonine-protein kinase 1 |
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Name: | Receptor-interacting serine/threonine-protein kinase 1 |
Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 75926.99 |
Organism: | Homo sapiens (Human) |
Description: | Q13546 |
Residue: | 671 |
Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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BDBM50229242 |
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n/a |
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Name | BDBM50229242 |
Synonyms: | CHEMBL4084908 |
Type | Small organic molecule |
Emp. Form. | C16H20F3NO |
Mol. Mass. | 299.3313 |
SMILES | CN(Cc1cc(F)cc(F)c1F)C(=O)C1(C)CCCCC1 |
Structure |
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