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TargetReceptor-interacting serine/threonine-protein kinase 1
LigandBDBM50229699
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1644186 (CHEMBL3993115)
EC50 125±n/a nM
Citation Ren, YSu, YSun, LHe, SMeng, LLiao, DLiu, XMa, YLiu, CLi, SRuan, HLei, XWang, XZhang, Z Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome. J Med Chem60:972-986 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Receptor-interacting serine/threonine-protein kinase 1
Name:Receptor-interacting serine/threonine-protein kinase 1
Synonyms:Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:Enzyme Catalytic Domain
Mol. Mass.:75926.99
Organism:Homo sapiens (Human)
Description:Q13546
Residue:671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50229699
n/a
NameBDBM50229699
Synonyms:CHEMBL4059584
TypeSmall organic molecule
Emp. Form.C14H20FNO
Mol. Mass.237.3131
SMILESCCC(C)(C)C(=O)N(C)Cc1ccccc1F
Structure
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