| Reaction Details |
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 | Report a problem with these data |
| Target | Sialic acid-binding Ig-like lectin 7 |
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| Ligand | BDBM50230648 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1644943 (CHEMBL3993872) |
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| IC50 | 36900000±n/a nM |
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| Citation |  Prescher, H; Frank, M; Gütgemann, S; Kuhfeldt, E; Schweizer, A; Nitschke, L; Watzl, C; Brossmer, R Design, Synthesis, and Biological Evaluation of Small, High-Affinity Siglec-7 Ligands: Toward Novel Inhibitors of Cancer Immune Evasion. J Med Chem60:941-956 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sialic acid-binding Ig-like lectin 7 |
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| Name: | Sialic acid-binding Ig-like lectin 7 |
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| Synonyms: | AIRM-1 | AIRM1 | Adhesion inhibitory receptor molecule 1 | CD_antigen=CD328 | CDw328 | D-siglec | QA79 membrane protein | SIGL7_HUMAN | SIGLEC7 | Sialic acid-binding Ig-like lectin 7 | Siglec-7 | p75 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51147.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109858 |
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| Residue: | 467 |
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| Sequence: | MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDP
VHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGR
YFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPP
MISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPP
QNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQP
SNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAG
ATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPR
HHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK
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| BDBM50230648 |
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| n/a |
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| Name | BDBM50230648 |
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| Synonyms: | CHEMBL3764379 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H39NO19 |
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| Mol. Mass. | 633.5511 |
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| SMILES | [H][C@@]1(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)O[C@H](CO)[C@H](O)[C@H](O[C@@]2(C[C@H](O)[C@@H](NC(C)=O)[C@@]([H])(O2)[C@H](O)[C@H](O)CO)C(O)=O)[C@H]1O |r| |
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| Structure | 
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