| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM50231393 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1645327 (CHEMBL3994256) |
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| Ki | 260±n/a nM |
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| Citation |  Liu, T; Wan, Y; Liu, R; Ma, L; Li, M; Fang, H Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. Bioorg Med Chem25:1939-1948 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM50231393 |
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| n/a |
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| Name | BDBM50231393 |
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| Synonyms: | CHEMBL4073167 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H28Cl2N4O6S |
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| Mol. Mass. | 727.612 |
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| SMILES | [O-][N+](=O)c1cc(ccc1Cl)S(=O)(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cn(Cc2ccc(cc2)-c2ccc(Cl)cc2)c2ccccc12 |r| |
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| Structure | 
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