| Reaction Details |
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 | Report a problem with these data |
| Target | Glucagon-like peptide 1 receptor |
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| Ligand | BDBM50231886 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1645791 |
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| EC50 | 50±n/a nM |
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| Citation |  Plisson, F; Hill, TA; Mitchell, JM; Hoang, HN; de Araujo, AD; Xu, W; Cotterell, A; Edmonds, DJ; Stanton, RV; Derksen, DR; Loria, PM; Griffith, DA; Price, DA; Liras, S; Fairlie, DP Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling. Eur J Med Chem127:703-714 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucagon-like peptide 1 receptor |
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| Name: | Glucagon-like peptide 1 receptor |
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| Synonyms: | GLP1R_RAT | Glp1r | Glpr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52889.73 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_855307 |
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| Residue: | 463 |
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| Sequence: | MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGL
FCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPW
RDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERW
RLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
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| BDBM50231886 |
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| n/a |
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| Name | BDBM50231886 |
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| Synonyms: | CHEMBL4070761 |
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| Type | Small organic molecule |
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| Emp. Form. | C155H234N42O45 |
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| Mol. Mass. | 3405.7709 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| |
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| Structure | 
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