| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP15 |
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| Ligand | BDBM50316226 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1646315 |
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| IC50 | 28840±n/a nM |
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| Citation |  Thorsell, AG; Ekblad, T; Karlberg, T; Löw, M; Pinto, AF; Trésaugues, L; Moche, M; Cohen, MS; Schüler, H Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J Med Chem60:1262-1271 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP15 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP15 |
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| Synonyms: | (ARTD7 or PARP15) | (ARTD7 or PARP15, Y598L) | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 7 | ARTD7 | B-aggressive lymphoma protein 3 | BAL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD7 or PARP15, Y598L) | PAR15_HUMAN | PARP-15 | PARP15 | Poly [ADP-ribose] polymerase 15 | Synonyms=BAL3 |
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| Type: | n/a |
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| Mol. Mass.: | 74595.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q460N3 |
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| Residue: | 678 |
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| Sequence: | MAAPGPLPAAALSPGAPTPRELMHGVAGVTSRAGRDREAGSVLPAGNRGARKASRRSSSR
SMSRDNKFSKKDCLSIRNVVASIQTKEGLNLKLISGDVLYIWADVIVNSVPMNLQLGGGP
LSRAFLQKAGPMLQKELDDRRRETEEKVGNIFMTSGCNLDCKAVLHAVAPYWNNGAETSW
QIMANIIKKCLTTVEVLSFSSITFPMIGTGSLQFPKAVFAKLILSEVFEYSSSTRPITSP
LQEVHFLVYTNDDEGCQAFLDEFTNWSRINPNKARIPMAGDTQGVVGTVSKPCFTAYEMK
IGAITFQVATGDIATEQVDVIVNSTARTFNRKSGVSRAILEGAGQAVESECAVLAAQPHR
DFIITPGGCLKCKIIIHVPGGKDVRKTVTSVLEECEQRKYTSVSLPAIGTGNAGKNPITV
ADNIIDAIVDFSSQHSTPSLKTVKVVIFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTC
NLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVK
KRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSA
KDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLF
VVFFDNQAYPEYLITFTA
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| BDBM50316226 |
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| n/a |
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| Name | BDBM50316226 |
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| Synonyms: | (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide | CHEMBL1094636 | MK-4827 | Niraparib |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N4O |
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| Mol. Mass. | 320.3883 |
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| SMILES | NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1 |r| |
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| Structure | 
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