| Reaction Details |
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 | Report a problem with these data |
| Target | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2) |
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| Ligand | BDBM27566 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1646304 |
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| IC50 | 12±n/a nM |
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| Citation |  Thorsell AG; Ekblad T; Karlberg T; Löw M; Pinto AF; Trésaugues L; Moche M; Cohen MS; Schüler H Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J Med Chem 60:1262-1271 (2017) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2) |
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| Name: | PARP 1, 2 and 3 |
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| Synonyms: | (ARTD2 or PARP2) | Poly [ADP-ribose] polymerase 2 | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) | Poly [ADP-ribose] polymerase 3 (PARP3) |
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| Type: | Enyme |
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| Mol. Mass.: | 66225.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UGN5 |
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| Residue: | 583 |
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| Sequence: | MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
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| BDBM27566 |
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| n/a |
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| Name | BDBM27566 |
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| Synonyms: | 4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one | Acylpiperazine analogue, 47 | Olaparib | US10174023, AZD2281 | US9187430, AZD-2281 | US9255106, AZD2281 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23FN4O3 |
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| Mol. Mass. | 434.4628 |
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| SMILES | Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCN(CC1)C(=O)C1CC1 |
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| Structure | 
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