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TargetProtein mono-ADP-ribosyltransferase PARP12
LigandBDBM27566
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1646313 (CHEMBL3995369)
IC50 10050±n/a nM
Citation Thorsell, AGEkblad, TKarlberg, TLöw, MPinto, AFTrésaugues, LMoche, MCohen, MSSchüler, H Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J Med Chem60:1262-1271 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein mono-ADP-ribosyltransferase PARP12
Name:Protein mono-ADP-ribosyltransferase PARP12
Synonyms:ADP-ribosyltransferase diphtheria toxin-like 12 | ARTD12 | PAR12_HUMAN | PARP-12 | PARP12 | Poly [ADP-ribose] polymerase 12 | ZC3HDC1 | Zinc finger CCCH domain-containing protein 1
Type:PROTEIN
Mol. Mass.:79092.00
Organism:Homo sapiens (Human)
Description:ChEMBL_107665
Residue:701
Sequence:
MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAA
APERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTT
EHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHI
CQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAP
SRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYR
WQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLS
TASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGS
DGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPG
PKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEV
YQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARD
AAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSI
FVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM27566
n/a
NameBDBM27566
Synonyms:4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one | Acylpiperazine analogue, 47 | Olaparib | US10174023, AZD2281 | US10597399, Compound AZD2281 | US9187430, AZD-2281 | US9255106, AZD2281
TypeSmall organic molecule
Emp. Form.C24H23FN4O3
Mol. Mass.434.4628
SMILESFc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCN(CC1)C(=O)C1CC1
Structure
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