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TargetProstaglandin E receptor 4
LigandBDBM50232544
Substrate/Competitorn/a
Meas. Tech.ChEBML_1648046
Ki 38±n/a nM
Citation Okumura YYamagishi TNukui SNakao K Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist. Bioorg Med Chem Lett 27:1186-1192 (2017) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E receptor 4
Name:Prostaglandin E receptor 4
Synonyms:PTGER4 | Prostaglandin E receptor 4 | Prostaglandin E2 receptor EP4 subtype
Type:PROTEIN
Mol. Mass.:53444.07
Organism:Canis lupus familiaris
Description:ChEMBL_117515
Residue:492
Sequence:
MSTPGANASASSTPDRPNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGEALCEYSTFILLFFSLSGLSIICAMSIERYLA
INHAYFYSHYVDKRLAGLTLVAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHPAAGALAVPSAL
CRSHPAAAAPSPALPRLSDFRRRRSFRGIAGAEIQMVILLIATSLVVLICSIPLVVRVFI
NQLYQPRLVKEISKNPDLQAIRIAAVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGS
RRDRSGQHCSESRRTSSAMSGHSRSFLSRELKETSSTSQTLLYMPDLSENGLGGRNLLPG
VPGMGLPQADTTSLRTLRISETSDSSQGQDSESVLLVDEVGGSSHQSGPGPKGNSLQVTF
PNETLNLSEKCI
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  Blast E-value cutoff:
BDBM50232544
n/a
NameBDBM50232544
Synonyms:CHEMBL4099851
TypeSmall organic molecule
Emp. Form.C21H16ClFN2O4
Mol. Mass.414.814
SMILESC[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(cc1)C(O)=O |r|
Structure
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