Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 3A | ||
Ligand | BDBM50232604 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_1648184 | ||
IC50 | >100000±n/a nM | ||
Citation | Iwuagwu, C; King, D; McDonald, IM; Cook, J; Zusi, FC; Hill, MD; Mate, RA; Fang, H; Knox, R; Gallagher, L; Post-Munson Amy Easton, D; Miller, R; Benitex, Y; Siuciak, J; Lodge, N; Zaczek, R; Morgan, D; Bristow, L; Macor, JE; Olson, RE Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR. Bioorg Med Chem Lett27:1261-1266 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 3A | |||
Name: | 5-hydroxytryptamine receptor 3A | ||
Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 | ||
Type: | Protein | ||
Mol. Mass.: | 55283.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P46098 | ||
Residue: | 478 | ||
Sequence: |
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BDBM50232604 | |||
n/a | |||
Name | BDBM50232604 | ||
Synonyms: | CHEMBL4093500 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H21N5O | ||
Mol. Mass. | 335.4029 | ||
SMILES | C1N=C(Nc2cnc(cn2)-c2ccccc2)O[C@]11CN2CCC1CC2 |r,wU:17.18,t:1,TLB:16:17:21.20:23.24,THB:0:17:21.20:23.24,(5.45,-45.54,;6.6,-44.51,;5.98,-43.11,;6.75,-41.77,;8.29,-41.77,;9.05,-40.44,;10.59,-40.43,;11.36,-41.77,;10.6,-43.11,;9.06,-43.11,;12.9,-41.77,;13.67,-43.11,;15.21,-43.11,;15.99,-41.77,;15.21,-40.43,;13.67,-40.44,;4.44,-43.26,;4.12,-44.77,;4.11,-46.18,;1.94,-45.65,;1.95,-43.85,;2.52,-42.57,;2.59,-44.1,;1.2,-44.86,;.87,-46.41,)| | ||
Structure |