| Reaction Details |
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 | Report a problem with these data |
| Target | Lysyl oxidase homolog 2 |
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| Ligand | BDBM50232684 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1648485 (CHEMBL3997541) |
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| IC50 | 385±n/a nM |
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| Citation |  Hutchinson, JH; Rowbottom, MW; Lonergan, D; Darlington, J; Prodanovich, P; King, CD; Evans, JF; Bain, G Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett8:423-427 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysyl oxidase homolog 2 |
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| Name: | Lysyl oxidase homolog 2 |
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| Synonyms: | 1.4.3.13 | LOXL2 | LOXL2_HUMAN | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 | Lysyl oxidase-related protein 2 | Lysyl oxidase-related protein WS9-14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86721.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_115990 |
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| Residue: | 774 |
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| Sequence: | MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRL
AGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGP
IWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLN
IQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGER
TYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVS
CVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSA
SVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDA
GVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQL
GLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAG
VACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFS
SQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLED
TECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEV
AESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
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| BDBM50232684 |
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| n/a |
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| Name | BDBM50232684 |
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| Synonyms: | CHEMBL4103840 | US11358936, Compound 4-3 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H7FN2 |
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| Mol. Mass. | 126.1316 |
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| SMILES | NCc1ccnc(F)c1 |
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| Structure | 
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