| Reaction Details |
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 | Report a problem with these data |
| Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
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| Ligand | BDBM50232913 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1649546 (CHEMBL3998680) |
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| IC50 | 284±n/a nM |
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| Citation |  Tso, SC; Lou, M; Wu, CY; Gui, WJ; Chuang, JL; Morlock, LK; Williams, NS; Wynn, RM; Qi, X; Chuang, DT Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors. J Med Chem60:1142-1150 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
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| Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
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| Synonyms: | PDHK4 | PDK4 | PDK4_HUMAN | Pyruvate dehydrogenase kinase | Pyruvate dehydrogenase kinase 4 (PDK4) | Pyruvate dehydrogenase kinase isoform 4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 46469.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16654 |
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| Residue: | 411 |
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| Sequence: | MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQE
LPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTL
IKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIF
SDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIH
IVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPL
RIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDA
IIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
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| BDBM50232913 |
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| n/a |
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| Name | BDBM50232913 |
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| Synonyms: | CHEMBL4103350 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29N5O6S |
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| Mol. Mass. | 503.571 |
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| SMILES | N[C@@H](CC(N)=O)C(=O)N1CCC(CC1)Nc1ccc2CN(Cc2c1)S(=O)(=O)c1ccc(O)cc1O |r| |
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| Structure | 
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