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TargetCannabinoid receptor 1
LigandBDBM50232939
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1649598
Ki 322±n/a nM
Citation Ragusa GGómez-Cañas MMorales PRodríguez-Cueto CPazos MRAsproni BCichero EFossa PPinna GAJagerovic NFernández-Ruiz JMurineddu G New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking. Eur J Med Chem 127:398-412 (2017) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50232939
n/a
NameBDBM50232939
Synonyms:CHEMBL4104545
TypeSmall organic molecule
Emp. Form.C25H26FN3O2
Mol. Mass.419.4912
SMILESC[C@H]1CC[C@@H](CC1)NC(=O)c1cc(nn(Cc2ccc(F)cc2)c1=O)-c1ccccc1 |r,wU:1.0,wD:4.7,(18.74,-30.37,;17.96,-31.7,;18.71,-33.03,;17.93,-34.35,;16.4,-34.33,;15.63,-33,;16.42,-31.68,;15.61,-35.66,;14.07,-35.65,;13.31,-34.31,;13.29,-36.98,;11.74,-36.97,;10.98,-38.3,;11.74,-39.64,;13.27,-39.65,;14.03,-40.99,;13.25,-42.32,;11.71,-42.3,;10.93,-43.62,;11.69,-44.96,;10.91,-46.29,;13.24,-44.97,;14.01,-43.64,;14.05,-38.32,;15.59,-38.33,;9.44,-38.29,;8.66,-39.62,;7.12,-39.62,;6.36,-38.27,;7.13,-36.94,;8.67,-36.95,)|
Structure
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