| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
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| Ligand | BDBM50233225 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1650179 (CHEMBL3999313) |
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| IC50 | 2500±n/a nM |
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| Citation |  Harris, PA; Berger, SB; Jeong, JU; Nagilla, R; Bandyopadhyay, D; Campobasso, N; Capriotti, CA; Cox, JA; Dare, L; Dong, X; Eidam, PM; Finger, JN; Hoffman, SJ; Kang, J; Kasparcova, V; King, BW; Lehr, R; Lan, Y; Leister, LK; Lich, JD; MacDonald, TT; Miller, NA; Ouellette, MT; Pao, CS; Rahman, A; Reilly, MA; Rendina, AR; Rivera, EJ; Schaeffer, MC; Sehon, CA; Singhaus, RR; Sun, HH; Swift, BA; Totoritis, RD; Vossenkämper, A; Ward, P; Wisnoski, DD; Zhang, D; Marquis, RW; Gough, PJ; Bertin, J Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. J Med Chem60:1247-1261 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 1 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
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| Synonyms: | Cell death protein RIP | RIP-1 | RIPK1_MOUSE | Receptor-interacting protein 1 | Receptor-interacting serine/threonine-protein kinase 1 | Rinp | Rinp | Rip | Ripk1 | Serine/threonine-protein kinase RIP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74852.62 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_116773 |
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| Residue: | 656 |
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| Sequence: | MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVL
LEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIV
EAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVS
STTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVI
CIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEE
DVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSS
SPEYPQDENDRSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERKRRVSHDPFA
QQRARENIKSAGARGHSDPSTTSRGIAVQQLSWPATQTVWNNGLYNQHGFGTTGTGVWYP
PNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGL
NSQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEI
DHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRASQS
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| BDBM50233225 |
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| n/a |
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| Name | BDBM50233225 |
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| Synonyms: | CHEMBL4071864 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N5O3 |
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| Mol. Mass. | 377.3966 |
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| SMILES | CN1c2ccccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O |r| |
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| Structure | 
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