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TargetReceptor-interacting serine/threonine-protein kinase 1
LigandBDBM50159508
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1650162 (CHEMBL3999296)
IC50 0.790000±n/a nM
Citation Harris, PABerger, SBJeong, JUNagilla, RBandyopadhyay, DCampobasso, NCapriotti, CACox, JADare, LDong, XEidam, PMFinger, JNHoffman, SJKang, JKasparcova, VKing, BWLehr, RLan, YLeister, LKLich, JDMacDonald, TTMiller, NAOuellette, MTPao, CSRahman, AReilly, MARendina, ARRivera, EJSchaeffer, MCSehon, CASinghaus, RRSun, HHSwift, BATotoritis, RDVossenkämper, AWard, PWisnoski, DDZhang, DMarquis, RWGough, PJBertin, J Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. J Med Chem60:1247-1261 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Receptor-interacting serine/threonine-protein kinase 1
Name:Receptor-interacting serine/threonine-protein kinase 1
Synonyms:Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:Enzyme Catalytic Domain
Mol. Mass.:75926.99
Organism:Homo sapiens (Human)
Description:Q13546
Residue:671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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  Blast E-value cutoff:
BDBM50159508
n/a
NameBDBM50159508
Synonyms:CHEMBL3786078
TypeSmall organic molecule
Emp. Form.C21H20N4O3
Mol. Mass.376.4085
SMILESCN1c2ccccc2NC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O |r|
Structure
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