| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
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| Ligand | BDBM50233250 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1650162 (CHEMBL3999296) |
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| IC50 | 1.000000±n/a nM |
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| Citation |  Harris, PA; Berger, SB; Jeong, JU; Nagilla, R; Bandyopadhyay, D; Campobasso, N; Capriotti, CA; Cox, JA; Dare, L; Dong, X; Eidam, PM; Finger, JN; Hoffman, SJ; Kang, J; Kasparcova, V; King, BW; Lehr, R; Lan, Y; Leister, LK; Lich, JD; MacDonald, TT; Miller, NA; Ouellette, MT; Pao, CS; Rahman, A; Reilly, MA; Rendina, AR; Rivera, EJ; Schaeffer, MC; Sehon, CA; Singhaus, RR; Sun, HH; Swift, BA; Totoritis, RD; Vossenkämper, A; Ward, P; Wisnoski, DD; Zhang, D; Marquis, RW; Gough, PJ; Bertin, J Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. J Med Chem60:1247-1261 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 1 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
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| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 75926.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13546 |
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| Residue: | 671 |
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| Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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| BDBM50233250 |
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| n/a |
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| Name | BDBM50233250 |
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| Synonyms: | CHEMBL4099698 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21N5O4 |
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| Mol. Mass. | 443.4546 |
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| SMILES | CN1c2cc(ccc2OC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O)-c1cc[nH]n1 |r| |
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| Structure | 
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