| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM50300305 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1650844 (CHEMBL3999978) |
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| Ki | 34000±n/a nM |
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| Citation |  Yue, EW; Sparks, R; Polam, P; Modi, D; Douty, B; Wayland, B; Glass, B; Takvorian, A; Glenn, J; Zhu, W; Bower, M; Liu, X; Leffet, L; Wang, Q; Bowman, KJ; Hansbury, MJ; Wei, M; Li, Y; Wynn, R; Burn, TC; Koblish, HK; Fridman, JS; Emm, T; Scherle, PA; Metcalf, B; Combs, AP INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology. ACS Med Chem Lett8:486-491 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM50300305 |
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| n/a |
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| Name | BDBM50300305 |
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| Synonyms: | 4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide | CHEMBL584991 | US10669273, Compound INCB024360 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H7ClFN5O2 |
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| Mol. Mass. | 271.636 |
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| SMILES | Nc1nonc1C(NO)=Nc1ccc(F)c(Cl)c1 |w:9.10| |
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| Structure | 
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