| Reaction Details |
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 | Report a problem with these data |
| Target | Dynamin-2 |
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| Ligand | BDBM50233969 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1651871 (CHEMBL4001126) |
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| IC50 | 1800±n/a nM |
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| Citation |  Odell, LR; Abdel-Hamid, MK; Hill, TA; Chau, N; Young, KA; Deane, FM; Sakoff, JA; Andersson, S; Daniel, JA; Robinson, PJ; McCluskey, A Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain. J Med Chem60:349-361 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dynamin-2 |
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| Name: | Dynamin-2 |
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| Synonyms: | DNM2 | DYN2 | DYN2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 98071.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_934670 |
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| Residue: | 870 |
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| Sequence: | MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPI
NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQK
DIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKL
QSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKL
KEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLID
IEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKE
YWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDL
RQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLV
DSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRD
DMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGR
PPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPP
GIPPGVPSRRPPAAPSRPTIIRPAEPSLLD
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| BDBM50233969 |
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| n/a |
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| Name | BDBM50233969 |
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| Synonyms: | CHEMBL4083788 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H35N5 |
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| Mol. Mass. | 321.504 |
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| SMILES | CCCCCCCCCCNc1cc(NCCN(C)C)ncn1 |
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| Structure | 
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