Reaction Details |
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Target | Heat shock factor protein 1 |
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Ligand | BDBM50153835 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1652055 (CHEMBL4001310) |
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IC50 | >10000±n/a nM |
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Citation | Cheeseman, MD; Chessum, NE; Rye, CS; Pasqua, AE; Tucker, MJ; Wilding, B; Evans, LE; Lepri, S; Richards, M; Sharp, SY; Ali, S; Rowlands, M; O'Fee, L; Miah, A; Hayes, A; Henley, AT; Powers, M; Te Poele, R; De Billy, E; Pellegrino, L; Raynaud, F; Burke, R; van Montfort, RL; Eccles, SA; Workman, P; Jones, K Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. J Med Chem60:180-201 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heat shock factor protein 1 |
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Name: | Heat shock factor protein 1 |
Synonyms: | HSF1 | HSF1_HUMAN | HSTF1 |
Type: | PROTEIN |
Mol. Mass.: | 57244.20 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1512556 |
Residue: | 529 |
Sequence: | MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY
SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE
PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR
PPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSP
SVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGS
VDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
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BDBM50153835 |
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n/a |
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Name | BDBM50153835 |
Synonyms: | 1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyphenylcarboxamido)-4-methylbenzene | 3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide | CHEMBL186526 | N-[5-(3-dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide | ZM-336372 |
Type | Small organic molecule |
Emp. Form. | C23H23N3O3 |
Mol. Mass. | 389.447 |
SMILES | CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(NC(=O)c2ccc(O)cc2)c1 |
Structure |
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