| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Heat shock factor protein 1 |
|---|
| Ligand | BDBM50234090 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1652055 (CHEMBL4001310) |
|---|
| IC50 | 51±n/a nM |
|---|
| Citation |  Cheeseman, MD; Chessum, NE; Rye, CS; Pasqua, AE; Tucker, MJ; Wilding, B; Evans, LE; Lepri, S; Richards, M; Sharp, SY; Ali, S; Rowlands, M; O'Fee, L; Miah, A; Hayes, A; Henley, AT; Powers, M; Te Poele, R; De Billy, E; Pellegrino, L; Raynaud, F; Burke, R; van Montfort, RL; Eccles, SA; Workman, P; Jones, K Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. J Med Chem60:180-201 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Heat shock factor protein 1 |
|---|
| Name: | Heat shock factor protein 1 |
|---|
| Synonyms: | HSF1 | HSF1_HUMAN | HSTF1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 57244.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1512556 |
|---|
| Residue: | 529 |
|---|
| Sequence: | MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY
SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE
PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR
PPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSP
SVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGS
VDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
|
|
|
|---|
| BDBM50234090 |
|---|
| n/a |
|---|
| Name | BDBM50234090 |
|---|
| Synonyms: | CHEMBL4069552 | US9701664, Example 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H21N3O4 |
|---|
| Mol. Mass. | 439.4626 |
|---|
| SMILES | Cc1ccc(NC(=O)c2ccc3OCCOc3c2)cc1NC(=O)c1ccc2ccncc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
