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TargetHeat shock factor protein 1
LigandBDBM50396483
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1652055 (CHEMBL4001310)
IC50>10000±n/a nM
Citation Cheeseman, MDChessum, NERye, CSPasqua, AETucker, MJWilding, BEvans, LELepri, SRichards, MSharp, SYAli, SRowlands, MO'Fee, LMiah, AHayes, AHenley, ATPowers, MTe Poele, RDe Billy, EPellegrino, LRaynaud, FBurke, Rvan Montfort, RLEccles, SAWorkman, PJones, K Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. J Med Chem60:180-201 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Heat shock factor protein 1
Name:Heat shock factor protein 1
Synonyms:HSF1 | HSF1_HUMAN | HSTF1
Type:PROTEIN
Mol. Mass.:57244.20
Organism:Homo sapiens (Human)
Description:ChEMBL_1512556
Residue:529
Sequence:
MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY
SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE
PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR
PPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSP
SVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGS
VDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50396483
n/a
NameBDBM50396483
Synonyms:PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemurafenib | US11332479, Compound Vemurafenib | US11492357, Control | US9388165, Reference, Vemurafenib (PLX-4032) | USRE47451, PLX-4032, Roche | VEMURAFENIB
TypeSmall organic molecule
Emp. Form.C23H18ClF2N3O3S
Mol. Mass.489.922
SMILESCCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Structure
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