| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50234135 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1652332 (CHEMBL4001587) |
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| IC50 | 1.14±n/a nM |
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| Citation |  Zhang, GQ; Jin, H; Zhao, Y; Guo, L; Gao, X; Wang, X; Tie, S; Shen, J; Wang, PG; Gan, H; Cui, H; Zhao, W An efficient anticoagulant candidate: Characterization, synthesis and in vivo study of a fondaparinux analogue Rrt1.17. Eur J Med Chem126:1039-1055 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50234135 |
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| n/a |
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| Name | BDBM50234135 |
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| Synonyms: | CHEMBL4072190 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H44N3Na9O47S7 |
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| Mol. Mass. | 1654.047 |
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| SMILES | [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[H][C@@]1(O[C@H]2[C@H](O)[C@@H](NS([O-])(=O)=O)[C@@H](OC)O[C@@H]2COS([O-])(=O)=O)O[C@@H](C([O-])=O)[C@@]([H])(O[C@@H]2O[C@H](COS([O-])(=O)=O)[C@@]([H])(O[C@@H]3O[C@H](C([O-])=O)[C@@]([H])(O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](O)[C@H](O)[C@H]4NC=O)[C@H](O)[C@H]3O)[C@H](OS([O-])(=O)=O)[C@H]2NS([O-])(=O)=O)[C@H](O)[C@H]1OS([O-])(=O)=O |r| |
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| Structure | 
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