| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-galactosidase A |
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| Ligand | BDBM50234563 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1653299 (CHEMBL4002665) |
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| IC50 | 30400±n/a nM |
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| Citation |  Cheng, WC; Wang, JH; Yun, WY; Li, HY; Hu, JM Rapid preparation of (3R,4S,5R) polyhydroxylated pyrrolidine-based libraries to discover a pharmacological chaperone for treatment of Fabry disease. Eur J Med Chem126:1-6 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-galactosidase A |
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| Name: | Alpha-galactosidase A |
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| Synonyms: | AGAL_HUMAN | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A) | GLA | INN=Agalsidase | Melibiase |
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| Type: | Protein |
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| Mol. Mass.: | 48760.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 429 |
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| Sequence: | MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEP
DSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQL
ANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENL
ADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIK
SILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDL
RHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIG
GPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENT
MQMSLKDLL
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| BDBM50234563 |
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| n/a |
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| Name | BDBM50234563 |
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| Synonyms: | CHEMBL4072729 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H28N2O7 |
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| Mol. Mass. | 384.4241 |
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| SMILES | COc1cc(OC)c(OC)cc1CCC(=O)NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O |r| |
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| Structure | 
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