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TargetProtein Mdm4
LigandBDBM50234681
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1653672 (CHEMBL4003038)
Ki 4290±n/a nM
Citation Surmiak, ENeochoritis, CGMusielak, BTwarda-Clapa, AKurpiewska, KDubin, GCamacho, CHolak, TADömling, A Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction. Eur J Med Chem126:384-407 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein Mdm4
Name:Protein Mdm4
Synonyms:Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:Oncoprotein
Mol. Mass.:54842.04
Organism:Homo sapiens (Human)
Description:The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50234681
n/a
NameBDBM50234681
Synonyms:CHEMBL4081794
TypeSmall organic molecule
Emp. Form.C30H30ClFN6O3
Mol. Mass.577.049
SMILESCCCCCNC(c1nnnn1Cc1ccc(OCc2ccccc2F)cc1)c1c([nH]c2cc(Cl)ccc12)C(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: