| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Mdm4 |
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| Ligand | BDBM50234678 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1653672 (CHEMBL4003038) |
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| Ki | 16170±n/a nM |
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| Citation |  Surmiak, E; Neochoritis, CG; Musielak, B; Twarda-Clapa, A; Kurpiewska, K; Dubin, G; Camacho, C; Holak, TA; Dömling, A Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction. Eur J Med Chem126:384-407 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein Mdm4 |
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| Name: | Protein Mdm4 |
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| Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 54842.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. |
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| Residue: | 490 |
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| Sequence: | MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
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| BDBM50234678 |
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| n/a |
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| Name | BDBM50234678 |
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| Synonyms: | CHEMBL4098742 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H31ClN6O3 |
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| Mol. Mass. | 571.069 |
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| SMILES | CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(NC1CCCC1)c1nnnn1-c1cccc(OCc2ccccc2)c1 |
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| Structure | 
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