| Reaction Details |
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 | Report a problem with these data |
| Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Ligand | BDBM50234713 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1653676 (CHEMBL4003042) |
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| IC50 | 2690±n/a nM |
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| Citation |  Miliutina, M; Ejaz, SA; Khan, SU; Iaroshenko, VO; Villinger, A; Iqbal, J; Langer, P Synthesis, alkaline phosphatase inhibition studies and molecular docking of novel derivatives of 4-quinolones. Eur J Med Chem126:408-420 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alkaline phosphatase, tissue-nonspecific isozyme |
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| Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Synonyms: | ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | PPBT_BOVIN | TNSALP | Tissue non-specific alkaline phosphatase (TNAP) |
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| Type: | Protein |
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| Mol. Mass.: | 57195.60 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P09487 |
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| Residue: | 524 |
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| Sequence: | MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDE
KARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELN
RNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIG
QAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYI
PHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
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| BDBM50234713 |
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| n/a |
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| Name | BDBM50234713 |
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| Synonyms: | CHEMBL4077772 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H15F3N2O3 |
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| Mol. Mass. | 424.372 |
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| SMILES | Cc1ccc(cc1)-c1[nH]c2ccc(cc2c(=O)c1-c1ccc(cc1)C(F)(F)F)[N+]([O-])=O |
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| Structure | 
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