| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP15 |
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| Ligand | BDBM50234915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1654158 (CHEMBL4003524) |
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| IC50 | >100000±n/a nM |
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| Citation |  Nathubhai, A; Haikarainen, T; Koivunen, J; Murthy, S; Koumanov, F; Lloyd, MD; Holman, GD; Pihlajaniemi, T; Tosh, D; Lehtiö, L; Threadgill, MD Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity. J Med Chem60:814-820 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP15 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP15 |
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| Synonyms: | (ARTD7 or PARP15) | (ARTD7 or PARP15, Y598L) | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 7 | ARTD7 | B-aggressive lymphoma protein 3 | BAL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD7 or PARP15, Y598L) | PAR15_HUMAN | PARP-15 | PARP15 | Poly [ADP-ribose] polymerase 15 | Synonyms=BAL3 |
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| Type: | n/a |
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| Mol. Mass.: | 74595.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q460N3 |
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| Residue: | 678 |
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| Sequence: | MAAPGPLPAAALSPGAPTPRELMHGVAGVTSRAGRDREAGSVLPAGNRGARKASRRSSSR
SMSRDNKFSKKDCLSIRNVVASIQTKEGLNLKLISGDVLYIWADVIVNSVPMNLQLGGGP
LSRAFLQKAGPMLQKELDDRRRETEEKVGNIFMTSGCNLDCKAVLHAVAPYWNNGAETSW
QIMANIIKKCLTTVEVLSFSSITFPMIGTGSLQFPKAVFAKLILSEVFEYSSSTRPITSP
LQEVHFLVYTNDDEGCQAFLDEFTNWSRINPNKARIPMAGDTQGVVGTVSKPCFTAYEMK
IGAITFQVATGDIATEQVDVIVNSTARTFNRKSGVSRAILEGAGQAVESECAVLAAQPHR
DFIITPGGCLKCKIIIHVPGGKDVRKTVTSVLEECEQRKYTSVSLPAIGTGNAGKNPITV
ADNIIDAIVDFSSQHSTPSLKTVKVVIFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTC
NLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVK
KRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSA
KDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLF
VVFFDNQAYPEYLITFTA
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| BDBM50234915 |
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| n/a |
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| Name | BDBM50234915 |
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| Synonyms: | CHEMBL4069447 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H23N5O3 |
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| Mol. Mass. | 477.5139 |
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| SMILES | Cc1cccc2c1nc(CCC(=O)Nc1ccc(cc1)C(=O)Nc1cccc3cccnc13)[nH]c2=O |
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| Structure | 
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