| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP3 |
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| Ligand | BDBM50234915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1654153 (CHEMBL4003519) |
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| IC50 | 45000±n/a nM |
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| Citation |  Nathubhai, A; Haikarainen, T; Koivunen, J; Murthy, S; Koumanov, F; Lloyd, MD; Holman, GD; Pihlajaniemi, T; Tosh, D; Lehtiö, L; Threadgill, MD Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity. J Med Chem60:814-820 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP3 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP3 |
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| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT-3 | ADPRT3 | ADPRTL3 | ARTD3 | IRT1 | NAD(+) ADP-ribosyltransferase 3 | PARP-3 | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly[ADP-ribose] synthase 3 | hPARP-3 | pADPRT-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60091.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109545 |
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| Residue: | 533 |
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| Sequence: | MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
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| BDBM50234915 |
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| n/a |
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| Name | BDBM50234915 |
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| Synonyms: | CHEMBL4069447 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H23N5O3 |
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| Mol. Mass. | 477.5139 |
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| SMILES | Cc1cccc2c1nc(CCC(=O)Nc1ccc(cc1)C(=O)Nc1cccc3cccnc13)[nH]c2=O |
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| Structure | 
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